Würzburg scientists develop a new diagnostic for SARS-CoV2 based on discoveries in pathogenic bacteria
Based on their discovery of non-canonical guide RNAs of the CRISPR/Cas system in the foodborne-pathogen Campylobacter, the labs of Cynthia Sharma (IMIB) and Chase Beisel (HIRI) have developed a novel multiplex diagnostic technology that makes tests for corona and other pathogens much more efficient.
Their study was published in the journal "Science" on Tuesday 27 April, 2021. read more...
Was sind Organoide?
ZINF junior group leader Sina Bartfeld explained the fascinating new models at the global stem cell day on March 5, 2021. (lecture was given in German) read more...
New Review on cross species RNA seq for deciphering host-microbe interactions
IMIB’s Jörg Vogel and Alexander Westermann provide a comprehensive review on the past, present and future of RNA-sequencing in the context of infections. The review was recently published in Nature Reviews Genetics. read more...
Orthogonal approaches are needed to identify the full targetome of a bacterial sRNA
The sRNA PinT helps Salmonella time its virulence expression along the infection cycle. This new study was led by the Würzburg laboratories of Jörg Vogel and Alexander Westermann. read more...
Jörg Vogel, again honoured as "highly cited researcher"
Jörg Vogel, founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) and director of the Institute for Molecular Infection Biology (IMIB) at the Julius-Maximilians-Universität Würzburg (JMU), is one of the most frequently cited researchers in his field. This is the result of an analysis published by Clarivate Analytics, a company specializing in citation data. read more...
New Salmonella proteins discovered
Only one small protein needs to be missing and salmonellae are no longer infectious. This was discovered in a study in which the pathogens were re-analysed using bioinformatics. The Würzburg laboratories of the Professors Jörg Vogel, Cynthia Sharma, Alexander Westermann, and Lars Barquist were involved in the study. read more...
Prof. Jörg Vogel announced as new president of the European Academy of Microbiology
Prof. Jörg Vogel, Director of the IMIB and HIRI has been announced as the President of the European Academy of Microbiology (EAM) from 1 January 2021. Prof. Vogel will take over from Prof Philippe Sansonetti, the former President of the Academy since 2012. read more...
Coinfection: More than the sum of its parts
Würzburg researchers and partners establish new technology to unravel genetic changes during infection with two different pathogens
Infections with two pathogens pose a serious threat in the clinics. Researchers from Würzburg and Jena have developed a technique that provides new insights into this process and can be used as an early warning system. The research results have now been published in the journal Cell Reports. read more...
Small RNA as a Central Player in Infections
Helicobacter pylori uses several “virulence” factors that allow it to survive in the stomach and can lead to the development of disease. Professor Cynthia Sharma's research team report that multiple of these factors are centrally regulated by a small RNA molecule called NikS. read more...
(free access): https://authors.elsevier.com/a/1bvij3vVUPDfNx
PhD award for Dr. Mona Alzheimer
Many congratulations to Dr. Mona Alzheimer (AG Sharma), who has been awarded the 2020 joint PhD award of the Lower Franconian Memorial Year Foundation for Science and the University of Würzburg for her PhD thesis on “Development of tissue-engineered three-dimensional infection models to study pathogenesis of Campylobacter jejuni”. read more...
Leap forward in the fight against antibiotic resistance
HIRI and IMIB researchers succeed in deep sequencing RNA of single bacteria. The study was published in the journal Nature Microbiology.
Bacteria show a wide range of capabilities in withstanding antibiotic treatment or attack by our immune system, which are great challenges in infection research. Now, a collaboration between scientists at the IMIB and the Würzburg-based Helmholtz Institute for RNA-based Infection Research (HIRI) have developed a novel approach to reading the activity of hundreds of genes in an individual bacterium by sequencing its RNA read more...
Location, location, location – even gut immune response is site-specific
Researchers at Würzburg University are using mini-organs to model the digestive tract in the laboratory. These so-called organoids provide insights into the inflammatory processes that play a role in diseases such Crohn’s and ulcerative colitis. In collaboration with surgeon Armin Wiegering from the University Hospital of Würzburg, Dr. Bartfeld’s team generated organoids from stomach, small intestine and colon. They discovered an unexpectedly large molecular complexity, as revealed by RNA sequencing, which reflects the gene activity of the cells. read more...
Fighting against multi-resistant bacteria
In their search for new therapeutic strategies, Würzburg research groups employ modern digital technologies. The Free State of Bavaria provides millions for this purpose.
Developing fundamentally new approaches against multi-resistant germs: This is the goal of the new Bavarian research network bayresq.net. The Free State of Bavaria is providing over ten million euros for this purpose. Research groups from the IMIB/ZINF are involved in two of the six funded projects. They will receive around 2.7 million euros over the next five years read more
Scientists resolve molecular architecture of a secretion systems involved in tuberculosis
Researchers at the Institute for Molecular Infection Biology and the Spanish Cancer Research Centre show a 3D model of a nanomachine used by Mycobacterium tuberculosis to block the immune response during infection. read more
Feldberg Prize awarded to Jörg Vogel News
Jörg Vogel has been awardewd the 2019 Feldberg prize. The Feldberg Foundation aims to promote scientific exchange between German and British researchers and is awarded annually to a scientist from each country based on their outstanding contribution to their respective research areas.
Poster Prize for Austin Mottola News
Congratulations to Austin Mottola (AG Morschhäuser), who won one of the five awarded poster prizes at the recent 71st Annual Conference of the German Society for Hygiene and Microbiology (DGHM), which took place from 25-27 February 2019 in Göttingen. (read more)
Drug-induced mating competence enables Candida albicans cells to combine individually aquired resistance mechanisms News
The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal drug fluconazole by various mechanisms, with clinically relevant high resistance levels requiring a combination of these mechanisms. Joachim Morschhäuser’s group from IMIB now report in mBio that under selective pressure by the drug, those cells in a population that have acquired resistance mutations undergo genetic recombination events that further increase drug resistance and simultaneously make this normally asexual fungus mating-competent. Mating of resistant cells and subsequent reassortment of their combined chromosome sets generates progeny that is highly drug-resistant. (read more)
ZINF and IMIB 25th Anniversary News
The Research Centre for Infectious Diseases (ZINF) and the Institute of Molecular Infection Biology (IMIB) at the University of Würzburg celebrated their 25th Anniversary with a scientific symposium on November 14th, 2018, covering the past and future of infectious diseases research. The day also celebrated Dr. Tobias Ölschläger’s many contributions and achievements over the years upon his retirement. (read more)
Genome organisation and structure controls antigenic variation News
How parasites modulate their surface proteins to evade recognition and elimination by the immune system remains poorly understood. Research at the ZINF by the team of Nicolai Siegel and reported in Nature, provides molecular insight into the role of genome structure and organisation in controlling antigenic variation in the parasite Trypanosoma brucei. (read more)
Jörg Vogel elected to the RNA Society Board of Directors News
Jörg Vogel has been elected to become a member of the RNA Society Board of Directors for 2019-2020. As part of the Board’s responsibilities he will be involved in developing and contributing to the long range planning of the Society.
Cas9 also cleaves RNA News
The discovery and development of the CRISPR-Cas9 system into a molecular tool that cleaves chosen DNA sequences is dramatically changing our ability to modify genomes. IMIB researchers led by Cynthia Sharma together with the lab of Chase Beisel now report in Molecular Cell that Cas9 can also cleave RNA – adding a new dimension to this flexible system for manipulating cells. (read more)
How a pathogenic fungus overcomes host defenses News
The yeast Candida albicans can be an opportunistic pathogen and also develop resistance to antimycotic drugs. IMIB researchers Irene Hampe and Joachim Morschhäuser report in PLoS Pathogens that the fungus becomes resistant to both drug therapy and innate host defenses by a related mechanism to establish itself in the oral cavity. (read more)
Heinz P.R. Seeliger prize for Prof. Dr. Joachim Morschhäuser News
IMIB professor Joachim Morschhäuser has been awarded the Heinz P.R. Seeliger prize for his research on the pathogenic yeast Candida albicans, especially for his pioneering work on antifungal drug resistance mechanisms. (read more)
Parasite gene expression - where to begin? News
Parasites such as Trypanosoma brucei use highly unusual strategies to regulate gene expression and despite intensive research it remains an enigma how control the initiation of transcription. New research from Carolin Wedel and ZINF Young Investigator Nicolai Siegel published in The EMBO Journal reveals a link between genome sequence, packaging and organisation in ensuring efficient gene expression. (read more)
New IMIB Professor News
Prof. Cynthia Sharma is the new Chair of Molecular Infection Biology II and member of the medical faculty at the Institute of Molecular Infection Biology (read more)
New RNA-centric Research Institute News
The Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, which will be led by IMIB Director Jörg Vogel, was officially established on 24th May 2017 (read more)
Zonta Prize for ZINF Young Investigator Sina Bartfeld News
The ZINF Young Investigator Sina Bartfeld has been awarded the Zonta Prize of the Zonta Club Würzburg. This prize is awarded annually to a highly qualified female scientist of the University of Würzburg. (read more)
DGHM and VAAM Poster Prize News
Congratulations to Bernardo Ramírez-Zavala (AG Morschhäuser), who won one of the ten awarded poster prizes at the recent 5th Joint Conference of the German Society for Hygiene and Microbiology (DGHM) & Association for General and Applied Microbiology (VAAM), which took place from 5-8 March 2017 in Würzburg. (read more)
IMIB scientists visit private donor Baldwin Knauf News
Jörg Vogel and ZINF Young Investigator Sina Bartfeld have visited Baldwin Knauf at the gypsum factory "Knauf Werke" in Iphofen. Baldwin Knauf generously supports research at the Institute of Molecular Infection Biology of the University Würzburg through donations. (read more)
Jörg Vogel arwarded the Gottfried Wilhelm Leibniz Prize News
Jörg Vogel has been awarded the Gottfried Wilhelm Leibniz Prize, the most prestigious research award in Germany. (read more)
ERC Starting Grant News
ZINF Young Investigator Nicolai Siegel has been awarded a highly prestigious European Research Council (ERC) Starting Grant for 1.5 million Euros over 5 years to study how genome organisation influences antigenic variation in parasites (read more)
Double Awards for Mona Alzheimer News
Mona Alzheimer, a PhD student in the Sharma group, has scooped two prizes at recent scientific meetings, the 12th International Workshop on Pathogenesis and Host Response in Helicobacter Infections and IZKF retreat (read more)
Jörg Vogel is elected to the European Academy of Microbiology News
Campylobacter post-transcriptional regulatory networks and RNA localization News
New research published in Nature Communications from the ZINF group of Cynthia Sharma and the group of Markus Sauer from the Biocenter describes the role of the post-transcriptional regulatory CsrA-FliW network in flagellar regulation of the human pathogen Campylobacter jejuni – a major cause of bacterial gastroenteritis. (read more)
Poster Awards News
Two PhD students from AG Morschhäuser, Irene Hampe and Christina Popp, received awards at the recent 13th ASM Conference on Candida and candidiasis, in Seattle, USA. (read more)
Parasitology Awards News
Heidrun Moll and Nicolai Siegel have been awarded the Rudolf Leuckart Medal and Karl Asmund Rudolphi Medal, respectively, of the German Society of Parasitology (read more)
New approach to understand host-pathogen interaction News
New research published in Nature from the IMIB group of Jörg Vogel describes a new method, dual RNA-seq, which provides insight into how pathogens change their gene expression patterns upon invading a eukaryotic cell and how the host cell responds to the infection. (read more)
Volkswagen Foundation News
Christian Perez has received funding from the Volkswagen Foundation’s Experiment! program. (read more)
Humboldt Fellowship News
Raúl Cosentino (AG Siegel) has been awarded a Georg Forster Research Fellowship from the Alexander von Humboldt Foundation (read more)
EMBO Young Investigator News
Ana Eulalio (BioSysNet Young Investigator) has been selected as an EMBO Young Investigator (read more)
Editorial Board Appointment News
Professor Heidrun Moll has been appointed to the Editorial Board of the new open access journal Parasite Epidemiology and Control. (read more)
Poster prize winners News
Congratulations to Lena Böhm (AG Perez) and Irene Hampe (AG Morschhäuser), who both won poster prizes at the recent joint 49th Scientific Conference of the German Speaking Mycological Society and 1st International Symposium of the CRC/Transregio FungiNet. (read more)
Best talk prize at the ISMB/ECCB News
Malvika Sharan (AG Eulalio and Vogel) has been awarded the best talk prize in the Automated Function Prediction Proceedings at the joint annual international conference on Intelligent Systems for Molecular Biology (ISMB) and the European Conference on Computational Biology (ECCB), which took place in Dublin, Ireland. Malvika presented APRICOT, which is the tool that she has developed for identifying RNA-binding proteins and protein-RNA interactions.
Cynthia Sharma from the Research Center for Infectious Diseases (ZINF) is one of ten researchers to be awarded the most important prize for young investigators in Germany. The prize is awarded annually by the German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) as a distinction for outstanding achievement [read more].
Infect-ERA funding for IMIB and ZINF Researchers News
Cynthia Sharma, Ana Eulalio and Jörg Vogel have been awarded funding for projects as part of the Infect-ERA program to coordinate European funding for infectious diseases research [read more].
Evaluation of cellular circuits News
Christian Perez has received funding from the Bavaria California Technology Center (BaCaTeC) to facilitate his work with Prof. Polly Fordyce at Stanford University on the molecular mechanism involved in the evolution of gene regulatory circuits in Candida albicans [read more]
Graduate School of Life Sciences Fellowships News
Congratulations to IMIB PhD candidates Laura Müller and Sarah Eisenbart who have been awarded PhD fellowships from the University of Wurzburgâ€™s Graduate School of Life Sciences. [read more]
Antibiotic Resistance Research News
Antibiotic resistant bacteria are a matter of increasing medical and public concern. The issue is highlighted in DIE ZEIT (20th Nov) and covers the link between industrialised animal husbandry and the occurrence of multidrug resistant human pathogens such as methicillin-resistant S. aureus (MRSA) – a topic of research at IMIB. [read more]
Robert Koch Postdoctoral Prize News
Kai Papenfort has been awarded the Robert Koch Postdoctoral Prize for his work on the role of small RNAs in Salmonella performed during his time at the IMIB [read more]
EMBO Practical CourseNon-coding RNA in Infection News
The first EMBO Practical Course Non-coding RNA in Infection was held at the Institute for Molecular Infection Biology during October. The course included lectures from many leading scientists in RNA Biology [read more]
RNase Controls Malaria Parasite Antigen Expression News
The molecular basis for how the malaria parasite Plasmodium falciparum evades the host immune system is not well understood. Work from ZINF Young Investigator Nicolai Siegel together with researchers at the Pasteur Institute published in Nature reveals an unanticipated role for an RNase in the process. [read more]
Evolution of Antibiotic Resistance News
Reporting in the journal Cell, the laboratory of ZINF Young Investigator Daniel Lopez has revealed a new route by which the bacterial pathogen Staphylococcus aureus can evolve vancomycin resistance in the absence of the antibiotic but involving interactions between different subpopulations of cells. [read more]
Poster Prize for Sarah Eisenbart News
Congratulations to master student (M.Sc. Biomedicine) Sara Eisenbart from AG Sharma who was recently awarded at the "11th International Workshop on Pathogenesis and Host Response in Helicobacter Infections" in HelsingÃ¸r, Denmark. [read more]
Jörg Vogel elected to German Academy of Sciences News
Jörg Vogel has been inaugurated into the German Academy of Sciences – Leopoldina. He received his certificate from the President of the Society Jörg Hacker during a ceremony in Halle. [read more]
Funding Renewal for Collaborative Research Centre 34 News
The Collaborative Research Centre 34 - Pathophysiology of Staphylococci in the Post-Genome-Era has been successfully evaluated and approved for the final round of funding by the DFG. IMIB members direct four projects in the network. [read more]
ESCMID Grant News
Cynthia Sharma has been awarded a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) grant.[read more]
Helicobacter host adaptation News
Understanding how bacterial pathogens adapt and take advantage of changing environmental conditions not only provides new insight into the cause and persistence of infectious diseases but also identifies new potential intervention strategies. New research published in the recent issue of the Proceedings of the National Academy of Sciences (PNAS 111(4):E501-10) from the ZINF young investigator group of Cynthia Sharma demonstrates how variable DNA sequences in the gastric pathogen Helicobacter pylori determine the outcome and fine-tuning of small RNA-mediated post-transcriptional gene expression control. [read more]
Oct 2013 News
DGHM Förderpreis 2013
Congratulations to Cynthia Sharma who has recently received the Förderpreis 2013 of the DGHM foundation at the Annual Meeting of the Deutsche Gesellschaft für Hygiene und Mikrobiologie. [read more]
Sept 2013 News
Congratulations to Tobias Ölschläger and his lab for winning a Poster Prize at the recent Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) Conference [read more]
Sept 2013 News
Congratulations to Mona Alzheimer (AG Sharma) and Sandy Pernitzsch (AG Sharma) who both won poster prizes at the recent International Workshop on Campylobacter, Helicobacter and Related Organisms. [read more]
Jul 2013 News
Congratulations to Daniel Lopez who has been awarded a highly prestigious European Research Council (ERC) Starting Grant for 1.5 million Euros over 5 years to study the role of cell signalling in bacterial pathogenesis.
Jul 2013 News
Congratulations to Erik Holmqvist (Vogel lab) who has been awarded a highly prestigious Wenner-Gren Fellowship by the Wenner-Gren Foundation in Sweden.
Jun 2013 News
20 years of ZINF
In 2013 the Research Center for Infectious Diseases (ZINF) and the Institute for Molecular Infection Biology (IMIB) will celebrate their 20th anniversaries. We will therefore organize a symposium to mark the anniversary that will be called: The New Infection Biology, 28 June 2013. During the symposium we will discuss the future prospects for Infection Research both in Würzburg and globally.
Jun 2013 News
Congratulations to Yanjie Chao (Vogel lab) who has received an award from the China Scholarship Council based in his outstanding performance during his PhD studies.
Jun 2013 News
The 3rd International Conference on “Regulating with RNA in Bacteriaâ€
The conference will take place at the Institute of Molecular Infection Biology (IMIB) from June 4th to 8th 2013.
Jun 2013 News
Lecture by Nobel Prize laureate Sidney Altman
The keynote lecture “The RNA-Protein Worldâ€ will be given by Prof. Sidney Altman (Yale University, USA) on 4 June 2013 at 7pm at the IMIB, Josef-Schneider-Str.2, D15. Prof. Altman received the Nobel Prize in Chemistry together with Thomas R. Cech for their discovery of the catalytic properties of RNA.
Apr 2013 News
Non-coding RNAs Hit The Sweet Spot
New research published in Cell from the IMIB group of Jörg Vogel provides new insight into how bacteria rapidly respond to sugar stress by using a novel RNA-based mechanism of gene activation to rapidly export toxic sugars [read more]
Mar 2013 News
FEBS Young Investigator Award
Congratulations to Ana Eulalio who has recieved the FEBS Young Investigator Award for her post-doctoral work on the role of miRNAs in cardiac regeneration. [read more]
Mar 2013 News
Fellow of American Academy of Microbology
Jörg Vogel has been elected a Fellow of the American Academy of Microbiology. The Academy recognizes excellence, originality, and creativity in the microbiological sciences. [read more]
Feb 2013 News
Postdoctoral Fellowship Award
Congratulations to Masatoshi Miyakoshi (Vogel Lab) who has been awarded a prestigious post-doctoral fellowship from the Japanese Society for the Promotion of Science (JSPS). The fellowships are awarded to young Japanese researchers to conduct research at foreign universities or research institutions for a period of two years. [read more]
Jan 2013 News
Fishing for compliment aids malaria parasite survival
New research published in Cell Host & Microbe by ZINF Young Investigator Gabriele Pradel provides new insight into how Plasmodium falciparum, the causative agent of malaria, hijacks a human protein to escape clearance by the innate immune system. [read more]
Graduate School of Life Siences Fellowhips
Congratulations to IMIB PhD candidates Benjamin Mielich-Süß and Caroline Tawk who have been awarded PhD fellowships from the University of Wurzburgâ€™s Graduate School of Life Sciences. [read more]
DFG supports Staphylococcus research at IMIB and ZINF
The Deutsche Forschungsgemeinschaft (DFG) has funded two research projects in the Lopez and Ziebuhr labs that aim to provide new insight into Staphylococci infections. (read more)
Alex Westermann in double prize glory
The first week of October turned out to be particular productive for PhD student Alex Westermann (Vogel lab) as his poster won top prize at two consecutive meetings. (read more)
Gene Expression in Trypanosoma brucei
The University of Würzburg is hosting the European Meeting on Gene Expression in Trypanosoma brucei on Sept 14th-16th 2012. (read more)
Further Funding for GSLS
The Graduate School of Life Sciences, University of Würzburg has been awarded further funding during the second phase of the German Excellence Initiative, which runs from 2012-2017. (read more)
Stipend award for Alex Westermann
Alex Westermann (Vogel lab) has been awarded an Elite Advancement PhD. stipend from the Universität Bayern e.V. The Universität Bayern e.V. is an organization representing the group of leading Bavarian Universities. (read more)
Funding for Cynthia Sharma by the Bavarian Academy of Sciences and Humanities
Congratulations to Cynthia Sharma on being recognised by the Bavarian Academy of Sciences and Humanities and admitted to their Förderkolleg for her work on Helicobacter pylori. (read more)
Long-term fellowship for Kai Papenfort
Kai Papenfort (Vogel lab) has been awarded a prestigious Human Frontiers Science Program (HFSP) long-term fellowship that will further support his career during his time in Princeton in the USA. (read more)
W2 professorship for Alex Boehm
Congratulations to Alex Böhm on accepting an offer of the W2 Professorship of Synthetic Microbiology at the LOEWE-Centre for Synthetic Microbiology at the University of Marburg, to where he will move his lab in July 2012. (read more)
W2 professorship for Sven Krappmann
Congratulations to Sven Krappmann on accepting an offer for the W2 Professorship of Clinical Microbiology and Immunonolgy at the University of Erlangen, Sven will move his lab to the University at the start of May 2012. (read more)
Scientific Coordinator at the IMIB
Dr. Stan Gorski has joined IMIB as a Scientific Coordinator from February 2012. He is affiliated with the Vogel lab, the IMIB and the Research Centre for Infectious diseases, ZINF. (read more)
Junior Research Group Position (BioSysNet)
March 19, 2012: Anna Eulalio has been awarded and accepted a junior research group position based on funding from the Bavarian Molecular Biosystems Research Network (BioSysNet). (read more)
New ZINF Young Investigator
February 15, 2012: Nicolai Siegel has arrived in Würzburg and started his new lab as a ZINF Young Investigator. The lab will focus on regulatory aspects of gene expression in African trypanosomes. (read more)
Postdoctoral Erwin Schrödinger fellowship
Congratulations to Dr. Gudrun Koch, who has been awarded a prestigious postdoctoral Erwin Schrödinger fellowship by the Austrian Science Fund (FWF). (read more)
November 25, 2011: Congratulations to ZINF Investigator Cynthia Sharma who is one of three young scientists to be awarded with a Post-doctoral Prize by the Robert Koch Foundation in 2011, in recognition of their outstanding work. (read more)
Jörg Vogel has been elected as an EMBO Member in the 2011 annual round of elections, as announced this week. He is among 43 renowned life scientists from fourteen countries across Europe whose excellence in research has been acknowledged by the Organization this year. (read more)
Mol Micro Meeting Würzburg April 25-27, 2012
We would like to invite you to the next 'Molecular Microbiology Meeting Würzburg, to be held at the Institute of Molecular Infection Biology in 2012. (read more)