Shazeb Ahmad     email
Helmholtz-Institute for RNA-based Infection Research (HIRI)

Supervisor:
Jun. Prof. Dr. Redmond Smyth (Würzburg)
Promotion Committee:
Jun. Prof. Dr. Redmond Smyth (Würzburg)
Dr. Antoine-Emmanuel Saliba  (Würzburg)
Prof. Dr. Christian Sieben  (HZI, Braunschweig)
Prof. Dr. Markus Sauer (Würzburg)

Understanding viral evolution by sequencing single viral particles genomes

Influenza viruses are responsible for recurrent epidemics and are a major burden on public health worldwide, causing an estimated 500,000 deaths each year. One of the most striking features of influenza is its segmented genome consisting of 8 negative stranded RNA segments (vRNAs). Although genome segmentation complicates virus assembly, it allows segment exchange between viruses by genetic reassortment. Reassortment is known to be non-random, but the molecular mechanism underlying this phenomenon is poorly understood. My project uses spatial transcriptomics to define pathways used by influenza to assemble its segmented genome into virions.