Doctoral Projects

The scientific programme of the Graduate Programme "Infectious Diseases Research" is based on the independent research projects of individual research groups cooperating within the framework of the Institute for Molecular Infection Biology and the Junior Groups of the Research Center for Infectious Diseases.

Picture of Mona Alzheimer

New 3D-infection models based on tissue-engeneering to study the pathogenesis of Helicobacter pylori and Campylobacter jejuni
>> more
Supervisor: Prof. Dr. Cynthia Sharma
Promotion Committee
: Prof. Dr. Cynthia Sharma, Prof. Dr. Heike Walles, Prof. Dr. Jörg Vogel

Riboregulation of meningococcal virulence
>>more
Supervisor:
Prof. Dr. Christoph Schoen
Promotion Committee:
Prof. Dr. Christoph Schoen, Prof. Dr. Jörg Vogel, Prof. Dr. Joachim Morschhäuser

Picture of Nico Dunkel

Regulatory circuits underlying host colonization by C. albicans
>>more
Supervisor:
Dr. J. Christian Pérez
Promotion Committee: Dr. J. Christian Pérez, Prof. Dr. Joachim Morschhäuser, Dr. Till Strowig, Dr. Kai Sohn

Understanding how a family of transcriptional regulators was repurposed to enable Candida albicans to thrive in mammalian hosts
>>more
Supervisor:
Dr. Christian Pérez
Promotion Committee: Dr. Christian Pérez, Prof. Dr. Joachim Morschhäuser, Prof. Dr. T. Nicolai Siegel, Dr. Polly Fordyce

Implementation and application of bioinformatical tools for the analysis of high-throughput sequencing data to detect RNA-protein and RNA-RNA interactions
>>more
Supervisor:
Dr. Konrad Förstner
Promotion Committee
: Prof. Dr. Jörg Vogel, Dr. Konrad Förstner, Prof. Dr. Thomas Dandekar

Functional analysis of HSV-1 induced transcription read-through
>>more

Supervisor:
Prof. Dr. Lars Dölken
Promotion Committee:  Prof. Dr. Lars Dölken, Prof. Dr. Utz Fischer, Jun.-Prof. Dr. Florian Erhard

Marie-Therese Eckstein

Investigating the interplay between bacterial and fungal members of the human gut microbiota 
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Supervisor: Dr. Christian Perez
Promotion Committee: Dr. Christian Perez, Dr. Martin Fraunholz, Prof. Dr. Julia-Stefanie Frick, Prof. Dr. Joachim Morschhäuser

Identification of auxiliary protein factors in post-transcriptional regulation in Epsilonproteobacteria
>>more
Supervisor:
Prof. Dr. Cynthia Sharma
Promotion Committee:
Prof. Dr. Cynthia Sharma, Prof. Dr. Thomas Rudel, Dr. Gisela Storz

Unraveling the Type VII secretion system (T7S) of Mycobacterium tuberculosis
>>more
Supervisor:
Dr. Sebastian Geibel
Promotion Commitee: Dr. Sebastian Geibel, Prof. Dr. Caroline Kisker, Dr. Clemens Grimm, Dr. Angel Rivera-Calzada

Identification and characterization of pseudouridine in RNAs of the human pathogen Campylobacter jejuni
>>more
Supervisor:
Prof. Dr. Cynthia Sharma
Promotion Committee: Prof. Dr. Cynthia Sharma, Prof. Dr. Utz Fischer, Prof. Dr. Dagmar Beier

Exploring small proteins in the foodborne pathogen Campylobacter jejuni
>>more

Supervisor:
Prof. Dr. Cynthia Sharma
Promotion Committee
: Prof. Dr. Cynthia Sharma, Prof. Dr. Chase Beisel, N.N.

Sara GomesMeningococcal ligands and molecular targets required for adhesion and penetration of the blood-cerebrospinal fluid barrier
>>more

Supervisor: Prof. Dr. Alexandra Schubert-Unkmeir
Promotion Committee:
Prof. Dr. Alexandra Schubert-Unkmeir, Dr. Marco Metzger, Dr. Maria Steinke, Antje Appelt-Menzel

Molecular characterization of the wnt-signaling pathway in Echinococcus multilocularis
>>more
Supervisor: Prof. Klaus Brehm
Promotion Commitee:
Prof. Klaus Brehm, Prof. Christian Janzen, Prof. Christian Stigloher

Serotonin signaling and mobile genetic elements in E. multiloculari
>>more
Supervisor:
Prof. Dr. Klaus Brehm
Promotion Committee:
Prof. Dr. Klaus Brehm, Prof. Dr. Nicolai Siegel, Prof. Dr. Jörg Schultz

Discovery of novel RNA-protein complexes by Grad-seq
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Supervisor:
Prof. Dr. Jörg Vogel
Promotion Committee:
Prof. Dr. Jörg Vogel, Prof. Dr. Cynthia Sharma, Prof. Dr. Utz Fischer

Regulation of antibiotic resistance in Staphylococcus aureus by small RNAs
>>more
Supervisor:
PD Dr.  Knut Ohlsen
Promotion Commitee:
PD Dr. Knut Ohlsen, PD Dr. Wilma Ziebuhr, Dr. Martin Fraunholz

Picture of Selina Kern

Molecular and functional characterization of the ser/thr kinase PknB and phosphatase Stp of Staphylococcus aureus
>>more

Supervisor: PD Dr. Knut Ohlsen
Promotion committee:
PD Dr. Knut Ohlsen, PD Dr. Wilma Ziebuhr, Prof. Dr. Susanne Engelmann

Chunlei Jiao

Developing a programmable mRNA-derived crRNA(mcrRNA) based CRISPR-Cas9 technology
>>more
Supervisor:
Prof. Dr. Chase Beisel (Würzburg)
Promotion Committee: Prof. Dr. Chase Beisel (Würzburg), Prof. Dr. Cynthia Sharma (Würzburg), Jun. Prof. Dr. Redmond Smyth (Würzburg)

Computional methods for systems virology of herpes viruses
>>more
Supervisor:
Jun.-Prof. Dr. Florian Erhard
Promotion Committee: Jun.-Prof. Dr. Florian Erhard, Prof. Dr. Lars Dölken, Prof. Dr. Thomas Dandekar, Prof. Dr. Sibylle Schneider-Schaulies

Analysis of the immune and mucosal barrier functions along the gastrointestinal tract of mouse and human using organoids as a model
>>more

Supervisor: Dr. Sina Bartfeld
Promotion Committee: Dr. Sina Bartfeld, Prof. Dr. Thomas Rudel, Dr. Armin Wiegering, Dr. Bon-Kyong Koo

Exploring virulence factors and regulators of the food-borne pathogen Campylobacter jejuni in a human 3D tissue infection model
>>more
Supervisor: Prof. Dr. Cynthia Sharma
Promotion Committee: Prof. Dr. Cynthia Sharma, PD. Dr. Marco Metzger, Prof. Dr. Roy Gross

Picture of Andrea Kühn

Identification of factors responsible for the targeted deposition of histone variants in Trypanosoma brucei
>>more
Supervisor:
Prof. Dr. Nicolai Siegel
Promotion Committee: Prof. Dr. Nicolai Siegel, Dr. Sonja Lorenz, Prof. Dr. Christian Janzen, Prof. Dr. Andreas Schlosser

Picture of Andreas Kalbfleisch

Lara Kricks

Functional characterization of lipid rafts in bacteria
>>more
Supervisor:
Dr. Daniel López
Promotion Committee:
Dr. Daniel López, Prof. Dr. Kai Papenfort, Prof. Dr. Sibylle Schneider-Schaulies

Role of host cell microRNAs during infection by Staphylococcus aureus
>>more
Supervisor: Dr. Ana Eulalio
Promotion Committee: Dr. Ana Eulalio, Dr. Daniel López, Prof. Dr. Jörg Wischhusen

Picture of Jens Kupke

Functional analyses of capsule O-acetyltransferases of Neisseria meningitidis and Escherichia coli K1
>>more
Supervisor:
Prof. Dr. Ulrich Vogel
Promotion Committee: Prof. Dr. Ulrich Vogel, PD Dr. Knut Ohlsen, PD Dr. Martina Mühlenhoff

Unveiling the Hfq mediated RNA-RNA interactome of Salmonella Typihmurium
>>more
Supervisor: Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Kai Papenfort, Dr. Franziska Faber

Investigation of the Type VII secretion system in Staphylococcus aureus
>>more
Supervisor: Dr. Sebastian Geibel
Promotion Committee: Dr. Sebastian Geibel, Prof. Thomas Müller, Dr. Gilles Phan

Dual RNA-seq analysis of pathogen and host
>>more
Supervisor:
Dr. Lars Barquist
Promotion Committee:
Dr. Alexander Westermann, Prof. Dr. Konrad Förstner, Prof. Dr. Petra Dersch

Analysis of Candida albicans protein kinases in signaling pathways
>>more
Supervisor: Prof. Dr. Joachim Morschhäuser
Promotion committee: Prof. Dr. Joachim Morschhäuser, Dr. J. Christian Pérez, Prof. Dr. Bernhard Hube

Epigenetic regulation of monoallelic expression in Trypanosoma brucei
>>more
Supervisor: Prof. Dr. Nicolai Siegel
Promotion Committee: Prof. Dr. Nicolai Siegel, Prof. Dr. Markus Engstler, Dr. Susanne Fenz, Dr. Konrad Förstner

The roles of the anaphylatoxin receptors during invasive disease as well as mucosal colonization caused by Neisseria meningitidis
>>more
Supervisor:
Dr. Kay Johswich
Promotion Commitee:
Dr. Kay Johswich, Prof. Dr. Alexandra Schubert-Unkmeir, Dr. Martin Fraunholz

Analysis of Epstein-Barr Virus interactions with the human stomach using a primary gastric monolayer
modelsystem.
>>more

Supervisor: Dr. Sina Bartfeld
Promotion Committee
: Prof. Dr. Wolfgang Hammerschmidt, Prof. Dr. Andreas Rosenwald, Prof. Dr. Heike
Walles

 

Analysis of the functional relevance of sphingomyelinases and ceramide in meningococcal pathogenesis
>>more
Supervisor:
Prof. Dr. Alexandra Schubert-Unkmeir
Promotion Committee: Prof. Dr. Alexandra Schubert-Unkmeir, Prof. Dr. Markus Sauer, Dr. Kay Johswich

Investigation of the post-transcriptional regulation in Fusobacterium nucleatum
>>more
Supervisor: Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Chase Beisel, N.N.

Evolution of antifungal drug resistance in Candida albicans
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Supervisor: Prof. Dr. Joachim Morschhäuser
Promotion Committee: Prof. Dr. Joachim Morschhäuser, PD Dr. Wilma Ziebuhr, Prof. Dr. Frank Ebel

Role of two non-coding RNAs in regulation of biofilm formation in Staphylococcus epidermidis
>>more
Supervisor:
PD Dr. Wilma Ziebuhr
Promotion Committee:
PD Dr. Wilma Ziebuhr, Prof. Dr. med. Alexandra Schubert-Unkmeir, Dr. Martin Fraunholz

Mechanisms of host colonisation by the fungus Candida albicans
>>more

Supervisor: Dr. J. Christian Pérez
Promotion Committee
: Dr. J. Christian Pérez, Prof. Dr. Bernhard Hube, Prof. Dr. Joachim Morschhäuser

Establishing a human intestinal tissue model to study host and pathogen determinants that restrict Salmonella enterica infection
>>more
Supervisor: Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Nicolai Siegel, Prof. Dr. Jay Hinton

Implementation and application of bioinformatical tools for the analysis of dual RNA-sequencing data of host and pathogen during infection
>>more
Supervisor:
Prof. Dr. Konrad Förstner
Promotion Committee: Prof. Dr. Konrad Förstner, Prof. Dr. Thomas Dandekar, Jun. Prof. Dr. Alexander Westermann

Modulation of Microbiota by Antisense Oligonucleotides
>>more
Supervisor: Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Claudia Höbartner, Dr. Franziska Faber

Analysis of the changes in the transcriptome of EcN in the presence of human host cells or EHEC
>>more
Supervisor: ADr Dr. Tobias Ölschläger
Promotion Committee: ADr Dr. Tobias Ölschläger, Prof. Dr. Roy Gross, Dr. Konrad Förstner, Dr. Rudolf von Buenau

Picture of Ean Jeong

Interplay between Shigella infection and host cell microRNAs
>>more
Supervisor:
Dr. Ana Eulalio
Promotion Committee:
Dr. Ana Eulalio, Prof. Dr. Thomas Rudel, Dr. Miguel Mano

Characterization of small proteins in E. coli and Salmonella Typhimurium
>>more
Supervisor: Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Cynthia Sharma, PD Dr. Wilma Ziebuhr, Prof. Dr. Kai Papenfort

Picture of Nina Simon

Structural studies of bacterial lipid rafts
>>more
Supervisor:
Dr. Daniel López
Promotion Committee:
Dr. Daniel López, Prof. Dr. Nicolai Siegel, Prof. Dr. Samuel Wagner

Picture of Carolin Wedel

Relevance of the DNA sequence during nucleosome positioning in Trypanosoma brucei
>>more
Supervisor: Prof. Dr. Nicolai Siegel
Promotion Committee: Prof. Dr. Nicolai Siegel, Prof. Dr. Christian Janzen, Prof. Dr. Klaus Brehm

Regulation of methionine metabolism in staphylococci: Impact on fitness and virulence
>>more
Supervisor:
PD Dr. Wilma Ziebuhr
Promotion Committee: PD Dr. Wilma Ziebuhr, PD Dr. Knut Ohlsen, Prof. Dr. Caroline Kisker

Alternative functions of CRISPR-Cas
>>more
Supervisor:
Prof. Chase Beisel
Promotion Committee
: Prof. Chase Beisel, Prof. Cynthia Sharma, Jun. Prof. Neva Caliskan

Defining quaternary RNA architecture of influenza by RNA-RNA seq
>>more
Supervisor: Prof. Dr. Smyth
Promotion Committee: Prof. Dr. Smyth, Prof. Dr. Schneider-Schaulies, Prof. Dr. Sharma

Development and application of computational tools for RNA-seq based transcriptome annotations
>>more
Supervisor:
Prof. Dr. Jörg Vogel
Promotion Committee: Prof. Jörg Vogel, Prof. Thomas Dandekar, Prof. Dr. Cymthia Sharma