Doctoral Projects

    The scientific programme of the Graduate Programme "Infectious Diseases Research" is based on projects of the individual research groups of the Institute for Molecular Infection Biology (IMIB), the Young Investigator Groups of the Research Center for Infectious Diseases (ZINF), and the Helmholtz Institute for RNA-based Infection Research (HIRI).

     

     

    Biochemical dissection of RNA-protein complexes in the host response to infection
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    Supervisor: Dr. Mathias Munschauer
    Promotion Committee: Dr. Mathias Munschauer, Prof. Dr. Utz Fischer, Dr. Simone Backes

    Understanding viral evolution by sequencing single viral particles genomes
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    Supervisor: Jun. Prof. Dr. Redmond Smyth
    Promotion Committee: Jun. Prof. Dr. Redmond Smyth, Dr. Antoine-Emmanuel Saliba, Prof. Dr. Christian Sieben, Prof. Dr. Markus Sauer

    Multi-omic characterization of the Salmonella RNA-binding protein ProQ during infection of the murine typhoid model
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    Supervisor: Jun. Prof. Dr. Lars Barquist
    Promotion Committee: Jun. Prof. Dr. Lars Barquist, Jun. Prof. Dr.  Alexander Westermann, Prof. Dr. Thomas Dandekar, Dr. Sofia Forslund

    Influenza virus reassortment
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    Supervisor:
    Jun. Prof. Dr. Redmond Smyth
    Promotion Committee: Jun. Prof. Dr. Redmond Smyth, Dr. Antoine-Emmanuel Saliba, Prof. Dr. Bettina Böttcher, Dr. Simone Backes

    Approaching cellular heterogeneity in the abundant microbiota member Bacteroides thetaiotaomicron
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    Supervisor: Jun. Prof. Alexander Westermann
    Promotion Committee: Jun. Prof. Alexander Westermann, Dr. Ana Rita Brochado, Prof. Dr.Till Strowig, Prof Jorg Vogel

    Integrating single-cell multi-omics to decipher host-pathogen interactions
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    Supervisor:
     Dr. Antoine-Emmanuel Saliba
    Promotion Committee
    : Dr. Antoine-Emmanuel Saliba , Prof. Dr. Roy Gross, Jun.-Prof. Dr. Florian Erhard, Prof. Dr. Leif Erik Sander

    Functional analysis of HSV-1 induced transcription read-through
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    Supervisor:
    Prof. Dr. Lars Dölken
    Promotion Committee:  Prof. Dr. Lars Dölken, Prof. Dr. Utz Fischer, Jun. Prof. Dr. Florian Erhard

    Characterizing novel defense systems in bacteria
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    Supervisor:  Prof. Dr. Chase Beisel
    Promotion Committee:  Prof. Dr. Chase Beisel Jun.-Prof. Dr. Alexander Westermann, Dr. Ana Rita Brochado, Dr. Franziska Faber

    Exploring small proteins in the foodborne pathogen Campylobacter jejuni
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    Supervisor:
    Prof. Dr. Cynthia Sharma
    Promotion Committee
    : Prof. Dr. Cynthia Sharma, Prof. Dr. Chase Beisel, Prof. Dr. Susanne Engelmann

    Global discovery of Hfq associated RNAs in the enteric pathogen Clostridioides difficile
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    Supervisor: Dr. Franziska Faber
    Promotion Committee: Dr. Franziska Faber, Jun. Prof. Dr. Alexander J. Westermann, Dr. Meina Neumann-Schaal

    Biochemical dissection of protein-RNA interaction in viral infections
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    Supervisor: Dr. Mathias Munschauer
    Promotion Committee: Dr. Mathias Munschauer, Prof. Dr. Utz Fischer, Prof. Dr. Lars Dölken

    CRISPR-based combinatorial screens in bacteria
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    Supervisor: Prof. Dr. Chase L. Beisel
    Promotion Committee: Prof. Dr. Chase L. Beisel, Jun. Prof. Dr. Alexander Westermann, Dr. Ana Rita Brochado, Prof. Dr. Hardt

    Development of template-driven gene editing without DNA breaks
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    Supervisor: Prof. Dr. Chase Beisel
    Promotion Committee:
    Prof. Dr. Chase Beisel, Prof. Dr. Caroline Kisker, Prof. Dr. Claudia Höbartner, Jun. Prof. Dr. Alexander J. Westermann

    Molecular characterization of the wnt-signaling pathway in Echinococcus multilocularis
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    Supervisor: Prof. Klaus Brehm
    Promotion Commitee:
    Prof. Klaus Brehm, Prof. Christian Janzen, Prof. Christian Stigloher

    Investigating the effect of peptide nucleic acids on the gene expression profile of bacterial pathogenic communities using single-cell RNA-seq
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    Supervisor: Prof. Dr. Jörg Vogel
    Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Thomas Rudel, Dr. Antoine-Emmanuel Saliba

    Programming antisense oligonucleotides (ASOs)
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    Supervisor: Prof. Dr. Jörg Vogel
    Promotion committee:
    Prof. Dr. Jörg Vogel, Jun. Prof. Dr. Lars Barquist, Dr. Ana Rita Brochado

    Computional methods for systems virology of herpes viruses
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    Supervisor:
    Jun. Prof. Dr. Florian Erhard
    Promotion Committee: Jun. Prof. Dr. Florian Erhard, Prof. Dr. Lars Dölken, Prof. Dr. Thomas Dandekar, Prof. Dr. Sibylle Schneider-Schaulies

    Analysis of the immune and mucosal barrier functions along the gastrointestinal tract of mouse and human using organoids as a model
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    Supervisor: Dr. Sina Bartfeld
    Promotion Committee: Dr. Sina Bartfeld, Prof. Dr. Thomas Rudel, Dr. Armin Wiegering, Dr. Bon-Kyong Koo

    Global discovery and analysis of programmed ribosomal frameshifting in T-cells
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    Supervisor: Jun. Prof. Dr. Neva Caliskan
    Promotion Committee: Jun. Dr. Prof. Dr. Neva Caliskan, Jun. Prof. Dr. Redmond Smyth, Jun. Prof. Dr. Florian Erhard

    Molecular analysis of the flatworms' intra/intercellular signal transduction
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    Supervisor:
      Prof. Dr. Klaus Brehm
    Promotion Committee
    : Prof. Dr. Klaus Brehm,  Prof. Dr. Christian Stigloher, Dr. August Stich

    Exploring virulence factors and regulators of the food-borne pathogen Campylobacter jejuni in a human 3D tissue infection model
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    Supervisor: Prof. Dr. Cynthia Sharma
    Promotion Committee: Prof. Dr. Cynthia Sharma, PD. Dr. Marco Metzger, Prof. Dr. Roy Gross

    Establishment of spatial transcriptomics methods to resolve host-pathogen interactions
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    Supervisor: Dr. Antoine-Emmanuel Saliba
    Promotion Committee:
    Dr. Susanne Kramer, Prof. Dr. Sauer, Dr. Georg Zeller

    Identification and functional characterization of novel RNA-binding proteins in Clostridium difficile
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    Supervisor:
    Dr. Franziska Faber
    Promotion Committee: Dr. Franziska Faber, Dr. Lars Barquist, Dr. José Manuel Borrero-de Acuña

    Comprehensive reannotation of the human and murine cytomegalovirus genomes and characterisation of novel gene products and sORF-encoded peptides
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    Supervisor: Prof. Dr. Lars Dölken
    Promotion Committee: Prof. Dr. Lars Dölken, Prof. Dr. Utz Fischer, Asst. Prof. Dr. Vanda Juranic Lisnic, Jun. Prof. Florian Erhard

    Genomic and Internet based analysis of Coxiella burnetii
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    Supervisor: Prof. Dr. Thomas Dandekar
    Promotion Committee: Prof. Dr. Thomas Dandekar, Prof. Dr. Konrad Förstner, PD. Dr. Dimitrios Frangoulidis, Prof. Dr. Jörg Schultz

    Resistance against last resort antibiotics in staphylococci: Molecular mechanisms and RNA-based counteractions
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    Supervisor: PD Dr. Wilma Ziebuhr
    Promotion Committee: PD Dr. Wilma Ziebuhr, Dr. Martin Fraunholz, Prof. Dr. Ulrike Holzgrabe, Prof. Dr. Andrew Whitelaw

    Interactome study of HSV-1
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    Supervisor:
    Prof. Dr. med. Lars Dölken
    Promotion Committee
    : Prof. Dr. med. Lars Dölken, Prof. Dr. rer. nat. Beate Sodeik, Prof. Dr. Florian Erhard, Dr. Michael Weekes

    Integrative analyses of CMV translatomes and MHC-I ligandomes
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    Supervisor: Prof. Dr. Florian Erhard
    Promotion Committee: Prof. Dr. Florian Erhard , Prof. Dr. Lars Dölken, Prof. Dr. Andreas Schlosser, Dr. Anne Halenius

    Establishment of a human primary 3D model for colonization with anaerobic gut bacteria
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    Supervisor: Jun. Prof. Dr. Alexander Westermann
    Promotion Committee: Jun. Prof. Dr. Alexander Westermann, Prof. Dr. Roy Gross, PD Dr. Marco Metzger

    The CRISPR/Cas system in Neisseria meningitidis and its potential role in host cell adhesion
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    Supervisor: PD Dr. rer. nat. Dr. med. Christoph Schoen
    Promotion Committee: PD Dr. rer. nat. Dr. med. Christoph Schoen, PD Dr. Knut Ohlsen, Prof. Dr. Dagmar Beier

    Analysis of innate immune responses of gastrointestinal epithelium to infection using human organoids as model
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    Supervisor: Dr. Sina Bartfeld
    Promotion Committee: Dr Sina Bartfeld, Priv.-Doz. Dr. Marco Metzger, Prof. Dr. Tomas Rudel

     

    Studying human pathogens using organoid systems
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    Supervisor:
    Dr. Sina Bartfeld
    Promotion Committee: Dr. Sina Bartfel, Dr. Antoine-Emmanuel Saliba, Prof. Dr. Redmond Smyt, PD Dr. Vera Kozjak-Pavlovic

    Single-molecule approaches to study frameshifting mechanisms and efficiency
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    Supervisor: Jun. Prof. Dr. Neva Caliskan
    Promotion Committee: Jun. Prof. Dr. Neva Caliskan, Prof. Dr. Utz Fischer, Prof. Dr. Markus Sauer

    Analysis of the functional relevance of sphingomyelinases and ceramide in meningococcal pathogenesis
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    Supervisor:
    Prof. Dr. Alexandra Schubert-Unkmeir
    Promotion Committee: Prof. Dr. Alexandra Schubert-Unkmeir, Prof. Dr. Markus Sauer, Dr. Kay Johswich

    Investigation of the post-transcriptional regulation in Fusobacterium nucleatum
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    Supervisor: Prof. Dr. Jörg Vogel
    Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. Chase Beisel, N.N.

    Identification and functional characterization of in-vivo-relevant sRNAs in Bacteroides thetaiotaomicron
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    Supervisor: Jun. Prof. Dr. Alexander Westermann
    Promotion Committee: Jun. Prof. Dr. Alexander Westermann, Prof. Dr. Chase Beisel, Dr. Martin Fraunholz

    Implementation and application of bioinformatical tools for the analysis of dual RNA-sequencing data of host and pathogen during infection
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    Supervisor:
    Prof. Dr. Konrad Förstner
    Promotion Committee: Prof. Dr. Konrad Förstner, Prof. Dr. Thomas Dandekar, Jun. Prof. Dr. Alexander Westermann

    The functional relevance of the intestinal mycobiome in the pathogenesis of non-alcoholic fatty liver disease
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    Supervisor:
    Prof. Dr. med Oliver Kurzai
    Promotion Committee:
    Prof. Dr. med Oliver Kurzai, Prof. Dr med Andreas Geier, Prof. Dr. Christian Janzen

    Characterizing the temporal dynamics of host-pathogen interactions by combining single-cell nascent RNA-seq and genetic screen
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    Supervisor: Dr. Antoine-Emmanuel Saliba
    Promotion Committee: Dr. Antoine-Emmanuel Saliba, Prof. Dr. Chase Beisel, Prof. Dr. Thomas Rudel, Prof. Dr. Florian Erhard, Dr. Sophie Helaine

    Applications and outcomes of genome targeting by CRISPR-Cas systems in bacteria
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    Supervisor: Prof. Dr. Chase Beisel
    Promotion Committee: Dr. Ana Rita Brochado, Jun. Prof. Dr. Lars Barquist, Dr. Till Strowig

    Identification and Characterization of anti-CRISPR proteins
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    Supervisor:
    Prof. Dr. Chase Beisel
    Promotion Committee:
    Prof. Dr. Chase Beisel, PD Dr. Knut Ohlsen, Prof. Dr. Lars Barquist, Prof. Dr. Peter Fineran

    Identification and characterization of RNA-binding-proteins in cancer-associated Fusobacterium nucleatum
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    Supervisor: Prof. Dr. Jörg Vogel
    Promotion Committee: Prof. Dr. Jörg Vogel, Prof. Dr. rer. nat. Dr. med. Christoph U. Schoen, Prof. Dr. Dagmar Beier

    Liqing Ye

    Defining quaternary RNA architecture of influenza by RNA-RNA seq
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    Supervisor: Jun. Prof. Dr. Redmond Smyth Promotion
    Promotion Committee: Jun. Prof. Dr. Redmond Smyth, Prof. Dr. Sibylle Schneider-Schaulies, Prof. Dr. Cynthia Sharma

    Development of CRISPR/Cas method for Functional Genomics
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    Supervisor: Jun. Prof. Dr. Lars Barquist
    Promotion Committee: Jun. Prof. Dr. Lars Barquist; Prof. Dr. Chase Beise; Dr. Ana Rita Brochado; Dr. Tobias Müller