Nosocomial infections, Staphylococcus, MRSA, MRSE, epidemiology, MLST, biofilm formation, antibiotic resistance, IS256, gene regulation, microarrays, proteomics, sRNAs
Main research interests are the epidemiology, genetics and molecular biology of healthcare-associated Staphylococcus epidermidis and Staphylococcus aureus. In our laboratory we have a strong interest in teaming basic research with public health aiming at an in-depth understanding of staphylococcal disease and laying the basis for future innovative prevention and treatment strategies. The Ziebuhr laboratory has a track record in genetics and molecular biology of staphylococci and key technologies of genome and proteome research have been established which are currently being used
- to identify regulatory networks controlling gene expression, focussing specifically on biofilm regulation in S. epidermidis;
- to identify and functionally characterise small regulatory RNAs and their role in biofilm control and metabolic adaptation;
- to study the molecular function of insertion sequence element IS256 and its impact on genome flexibility and heterogenous gene expression in biofilm-forming S. epidermidis; and
- to conduct molecular epidemiological studies on the dissemination of nosocomial S. epidermidis and their role as reservoirs for the evolution and spread of novel antibiotic resistance genes.