Selected publications
Original articles
Ramírez-Zavala B, Krüger I, Dunker C, Jacobsen ID, Morschhäuser J (2022)
The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans
PLoS Pathog 18:e1010283
Omran RP, Ramírez-Zavala B, Tebung WA, Yao S, Feng J, Law C, Dumeaux V, Morschhäuser J, Whiteway M (2022)
The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans
Genetics 220:iyab155
Ramírez-Zavala B, Mottola A, Krüger I, Morschhäuser J (2021)
A suppressor mutation in the β-subunit Kis1 restores functionality of the SNF1 complex in Candida albicans snf4D mutant
mSphere 6:e00929-21
Mottola A, Ramírez-Zavala B, Hünniger K, Kurzai O, Morschhäuser J (2021)
The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans
Mol Microbiol 116:483-497
Mottola A, Schwanfelder S, Morschhäuser J (2020)
Generation of viable Candida albicans mutants lacking the “essential” protein kinase Snf1 by inducible gene deletion
mSphere 5:e00805-20
Mayr E‑M, Ramírez-Zavala B, Krüger I, Morschhäuser J (2020)
A zinc cluster transcription factor contributes to the intrinsic fluconazole resistance of Candida auris
mSphere 5:e00279-20
Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, Häder A, Krüger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, Hünniger K, Kniemeyer O, Brakhage AA, Morschhäuser J, Hube B, Vylkova S, Kurzai O, Martin R. (2020)
Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans
mBio 11:e00206-20
Mottola A, Morschhäuser J (2019)
An intragenic recombination event generates a Snf4-independent form of the essential protein kinase Snf1 in Candida albicans
mSphere 4:e00352-19
Popp C, Ramírez-Zavala B, Schwanfelder S, Krüger I, Morschhäuser J (2019)
Evolution of fluconazole-resistant Candida albicans strains by drug-induced mating competence and parasexual recombination
mBio 10:e02740-18
Ramírez-Zavala B, Manz H, Englert F, Rogers PD, Morschhäuser J (2018)
A hyperactive form of the zinc cluster transcription factor Stb5 causes YOR1 overexpression and beauvericin resistance in Candida albicans
Antimicrob Agents Chemother 62:e01655-18
Allert S, Förster TM, Svensson C-M, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B (2018)
Candida albicans-induced epithelial damage mediates translocation through intestinal barriers
mBio 9:e00915-18
Hampe IAI, Friedman J, Edgerton M, Morschhäuser J (2017)
An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses
PLoS Pathog 13:e1006655
Popp C, Hampe IAI, Hertlein T, Ohlsen K, Rogers PD, Morschhäuser J (2017)
Competitive fitness of fluconazole-resistant clinical Candida albicans strains
Antimicrob Agents Chemother 61:e00584-17
Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J (2017)
The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans
Mol Microbiol 104:989-1007
Ene IV, Lohse MB, Vladu AV, Morschhäuser J, Johnson AD, Bennett RJ (2016)
Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells
mBio 7:e01269-16
Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD (2016)
Systematic genetic screen for transcriptional regulators of the Candida albicans white-opaque switch
Genetics 203:1679-1692
Tebung WA, Choudhury BI, Tebbji F, Morschhäuser J, Whiteway M (2016)
Rewiring of the Ppr1 zinc cluster transcription factor from purine catabolism to pyrimidine biogenesis in the Saccharomycetaceae
Curr Biol 26:1677-1687
Schneider S, Morschhäuser J (2015)
Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors
Antimicrob Agents Chemother 59:558-569
Ramírez-Zavala B, Mogavero S, Schöller E, Sasse C, Rogers PD, Morschhäuser J (2014)
SAGA/ADA complex subunit Ada2 is required for Cap1-, but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1
Antimicrob Agents Chemother 58:5102-5110
Pannanusorn S, Ramírez-Zavala B, Lünsdorf H, Agerbert B, Morschhäuser J, Römling U (2014)
Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis
Eukaryot Cell 13:438-451.
Ramírez-Zavala B, Weyler M, Gildor T, Schmauch C, Kornitzer D, Arkowitz R, Morschhäuser J (2013)
Activation of the Cph1-dependent MAP kinase signaling pathway induces white-opaque switching in Candida albicans
PLoS Pathog 9:e1003696.
Schillig R, Morschhäuser J (2013)Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activationMol Microbiol 89:1003-1017.
Dunkel N, Hertlein T, Franz R, Reuß O, Sasse C, Schäfer T, Ohlsen T, Morschhäuser J (2013)
Role of different peptide transporters in nutrient acquisition in Candida albicans
Eukaryot Cell 12:520-528.
Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J (2013)
White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion
Eukaryot Cell 12:50-58
Sasse C, Dunkel N, Schäfer T, Schneider S, Dierolf F, Ohlsen K, Morschhäuser J (2012)
The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans
Mol Microbiol 86:539-556
Sasse C, Schillig R, Reimund A, Merk J, Morschhäuser J (2012)
Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1
Antimicrob Agents Chemother 56:4490-4494
Schubert S, Popp C, Rogers PD, Morschhäuser J (2011)
Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1
Eukaryot Cell 10:1110-1121
Schubert S, Barker KS, Znaidi S, Schneider S, Dierolf F, Dunkel N, Aid M, Boucher G, Rogers PD, Raymond M, Morschhäuser J (2011)
Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans
Antimicrob Agents Chemother 55:2212-2223
Mogavero S, Tavanti A, Senesi S, Rogers PD, Morschhäuser J (2011)
Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1
Antimicrob Agents Chemother 55:2061-2066
Neuhäuser B, Dunkel N, Satheesh SV, Morschhäuser J (2011)
Role of the Npr1 kinase in ammonium transport and signaling by the ammonium permease Mep2 in Candida albicans
Eukaryot Cell 10:332-342
Dunkel N, Morschhäuser J (2011)
Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4D sap5D sap6D mutant
Eukaryot Cell 10:54-62
Heilmann CJ, Schneider S, Barker KS, Rogers PD, Morschhäuser J (2010)
An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans
Antimicrob Agents Chemother 54:353-359
Dabas N, Schneider S, Morschhäuser J (2009)
Mutational analysis of the Candida albicans ammonium permease Mep2p reveals residues required for ammonium transport and signaling
Eukaryot Cell 8:147-160
Schubert S, Rogers PD, Morschhäuser J (2008)
Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains
Antimicrob Agents Chemother 52:4274-4280
Dunkel N, Blass J, Rogers PD, Morschhäuser J (2008)
Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
Mol Microbiol 69:827-840
Dabas N, Morschhäuser J (2008)
A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans
Mol Microbiol 69:586-602
Dunkel N, Liu TT, Barker KS, Homayouni R, Morschhäuser J, Rogers PD (2008)
A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate
Eukaryot Cell 7:1180-1190
Ramírez-Zavala B, Reuß O, Park Y-N, Ohlsen K, Morschhäuser J (2008)
Environmental induction of white-opaque switching in Candida albicans
PLoS Pathog 4:e1000089
Staib P, Lermann U, Blaß-Warmuth J, Degel B, Würzner R, Monod M, Schirmeister T, Morschhäuser J (2008)
Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
Antimicrob Agents Chemother 52:146-156
Morschhäuser J, Barker KS, Liu TT, Blaß-Warmuth J, Homayouni R, Rogers PD (2007)
The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
PLoS Pathog 3:e164
Dabas N, Morschhauser J (2007)
Control of ammonium permease expression and filamentous growth by the GATA transcription factors GLN3 and GAT1 in Candida albicans
Eukaryot Cell 6:875-888
Hiller D, Stahl S, Morschhäuser J (2006)
Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate
Antimicrob Agents Chemother 50:2300-2308
Bader T, Schröppel K, Bentink S, Agabian N, Köhler G, Morschhäuser J (2006)
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
Infect Immun 74:4366-4369
Reuß O, Morschhäuser J (2006)
A family of oligopeptide transporters is required for growth of Candida albicans on proteins
Mol Microbiol 60:795-812
Hiller D, Sanglard D, Morschhäuser J (2006)
Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans
Antimicrob Agents Chemother 50:1365-1371
Park Y‑N, Morschhäuser J (2005)
Candida albicans MTLa tup1D mutants can reversibly switch to mating-competent, filamentous growth forms
Mol Microbiol 58:1288-1302
Park Y-N, Morschhäuser J (2005)
Tetracycline-inducible gene expression and gene deletion in Candida albicans
Eukaryot Cell 4:1328-1342
Biswas K, Morschhäuser J (2005)
The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans
Mol Microbiol 56:649-669
Staib P, Morschhäuser J (2005)
Differential expression of the NRG1 repressor controls species-specific regulation of chlamydospore development in Candida albicans and Candida dubliniensis
Mol Microbiol 55:637-652
Reuß O, Vik A, Kolter R, Morschhäuser J (2004)
The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
Gene 341:119-127
Staib P, Binder A, Kretschmar M, Nichterlein T, Schröppel K, Morschhäuser J (2004)
Tec1p-independent activation of a hypha-associated Candida albicans virulence gene during infection
Infect Immun 72:2386-2389
Bader T, Bodendorfer B, Schröppel K, Morschhäuser J (2003)
Calcineurin is essential for virulence in Candida albicans
Infect Immun 71:5344-5354
Michel S, Ushinsky S, Klebl B, Leberer E, Thomas D, Whiteway M, Morschhäuser J (2002)
Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes
Mol Microbiol 46:269-280
Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene
Mol Microbiol 44:1351-1366
Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection
Infect Immun 70:921-927
Wirsching S, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)
MDR1-mediated drug resistance in Candida dubliniensis
Antimicrob Agents Chemother 45:3416-3421
Strauß A, Michel S, Morschhäuser J (2001)
Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans
J Bacteriol 183:3761-3769
Staib P, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)
Isogenic strain construction and gene targeting in Candida dubliniensis
J Bacteriol 183:2859-2865
Wirsching S, Michel S, Morschhäuser J (2000)
Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
Mol Microbiol 36:856-865
Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2000)
Differential activation of a Candida albicans virulence gene family during infection
Proc Natl Acad Sci U S A 97:6102-6107
Wirsching S, Michel S, Köhler G, Morschhäuser J (2000)
Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor
J Bacteriol 182:400-404
Morschhäuser J, Michel S, Staib P (1999)
Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination
Mol Microbiol 32:547-556
Staib P, Kretschmar M, Nichterlein T, Köhler G, Michel S, Hof H, Hacker J, Morschhäuser J (1999)
Host-induced, stage-specific virulence gene activation in Candida albicans during infection
Mol Microbiol 32:533-546
Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J (1998)
Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
Antimicrob Agents Chemother 42:3065-3072
Review articles
Morschhäuser J (2016)
The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen
J Microbiol 54:192-201
Morschhäuser J (2010)
Regulation of white-opaque switching in Candida albicans
Med Microbiol Immunol 199:165-172
Morschhäuser J (2010)
Regulation of multidrug resistance in pathogenic fungi
Fungal Genet Biol 47:94-106