Selected publications

    Original articles

    Ramírez-Zavala B, Krüger I, Dunker C, Jacobsen ID, Morschhäuser J (2022)
    The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans

    PLoS Pathog
    18:e1010283

     

    Omran RP, Ramírez-Zavala B, Tebung WA, Yao S, Feng J, Law C, Dumeaux V, Morschhäuser J, Whiteway M (2022)
    The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans
    Genetics
    220:iyab155

    Ramírez-Zavala B, Mottola A, Krüger I, Morschhäuser J (2021)
    A suppressor mutation in the β-subunit Kis1 restores functionality of the SNF1 complex in Candida albicans snf4D mutant
    mSphere
    6:e00929-21

     

    Mottola A, Ramírez-Zavala B, Hünniger K, Kurzai O, Morschhäuser J (2021)
    The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans

    Mol Microbiol
    116:483-497

     

    Mottola A, Schwanfelder S, Morschhäuser J (2020)
    Generation of viable Candida albicans mutants lacking the “essential” protein kinase Snf1 by inducible gene deletion
    mSphere 5:e00805-20

    Mayr E‑M, Ramírez-Zavala B, Krüger I, Morschhäuser J (2020)

    A zinc cluster transcription factor contributes to the intrinsic fluconazole resistance of Candida auris

    mSphere 5:e00279-20

     

    Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, Häder A, Krüger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, Hünniger K, Kniemeyer O, Brakhage AA, Morschhäuser J, Hube B, Vylkova S, Kurzai O, Martin R. (2020)

    Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans

    mBio 11:e00206-20

     

    Mottola A, Morschhäuser J (2019)

    An intragenic recombination event generates a Snf4-independent form of the essential protein kinase Snf1 in Candida albicans

    mSphere 4:e00352-19

     

    Popp C, Ramírez-Zavala B, Schwanfelder S, Krüger I, Morschhäuser J (2019)

    Evolution of fluconazole-resistant Candida albicans strains by drug-induced mating competence and parasexual recombination

    mBio 10:e02740-18

     

    Ramírez-Zavala B, Manz H, Englert F, Rogers PD, Morschhäuser J (2018)

    A hyperactive form of the zinc cluster transcription factor Stb5 causes YOR1 overexpression and beauvericin resistance in Candida albicans

    Antimicrob Agents Chemother 62:e01655-18

     

    Allert S, Förster TM, Svensson C-M, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B (2018)

    Candida albicans-induced epithelial damage mediates translocation through intestinal barriers

    mBio 9:e00915-18

     

    Hampe IAI, Friedman J, Edgerton M, Morschhäuser J (2017)

    An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses

    PLoS Pathog 13:e1006655

     

    Popp C, Hampe IAI, Hertlein T, Ohlsen K, Rogers PD, Morschhäuser J (2017)

    Competitive fitness of fluconazole-resistant clinical Candida albicans strains

    Antimicrob Agents Chemother 61:e00584-17

     

    Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J (2017)

    The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans

    Mol Microbiol 104:989-1007

     

    Ene IV, Lohse MB, Vladu AV, Morschhäuser J, Johnson AD, Bennett RJ (2016)

    Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells

    mBio 7:e01269-16

     

    Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD (2016)

    Systematic genetic screen for transcriptional regulators of the Candida albicans white-opaque switch

    Genetics 203:1679-1692

     

    Tebung WA, Choudhury BI, Tebbji F, Morschhäuser J, Whiteway M (2016)

    Rewiring of the Ppr1 zinc cluster transcription factor from purine catabolism to pyrimidine biogenesis in the Saccharomycetaceae

    Curr Biol 26:1677-1687

     

    Schneider S, Morschhäuser J (2015)

    Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors

    Antimicrob Agents Chemother 59:558-569

     

    Ramírez-Zavala B, Mogavero S, Schöller E, Sasse C, Rogers PD, Morschhäuser J (2014)

    SAGA/ADA complex subunit Ada2 is required for Cap1-, but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1

    Antimicrob Agents Chemother 58:5102-5110

     

    Pannanusorn S, Ramírez-Zavala B, Lünsdorf H, Agerbert B, Morschhäuser J, Römling U (2014)

    Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis

    Eukaryot Cell 13:438-451.

     

    Ramírez-Zavala B, Weyler M, Gildor T, Schmauch C, Kornitzer D, Arkowitz R, Morschhäuser J (2013)
    Activation of the Cph1-dependent MAP kinase signaling pathway induces white-opaque switching in Candida albicans

    PLoS Pathog
    9:e1003696.

    Schillig R, Morschhäuser J (2013)Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activationMol Microbiol 89:1003-1017.


    Dunkel N, Hertlein T, Franz R, Reuß O, Sasse C, Schäfer T, Ohlsen T, Morschhäuser J (2013)

    Role of different peptide transporters in nutrient acquisition in Candida albicans

    Eukaryot Cell
    12:520-528.
     

    Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J (2013)
    White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion

    Eukaryot Cell
    12:50-58

    Sasse C, Dunkel N, Schäfer T, Schneider S, Dierolf F, Ohlsen K, Morschhäuser J (2012)
    The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans

    Mol Microbiol
    86:539-556
     

    Sasse C, Schillig R, Reimund A, Merk J, Morschhäuser J (2012)
    Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1

    Antimicrob Agents Chemother
    56:4490-4494
     

    Schubert S, Popp C, Rogers PD, Morschhäuser J (2011)
    Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1

    Eukaryot Cell
    10:1110-1121
     

    Schubert S, Barker KS, Znaidi S, Schneider S, Dierolf F, Dunkel N, Aid M, Boucher G, Rogers PD, Raymond M, Morschhäuser J (2011)
    Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans

    Antimicrob Agents Chemother
    55:2212-2223
     

    Mogavero S, Tavanti A, Senesi S, Rogers PD, Morschhäuser J (2011)
    Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1

    Antimicrob Agents Chemother
    55:2061-2066
     

    Neuhäuser B, Dunkel N, Satheesh SV, Morschhäuser J (2011)
    Role of the Npr1 kinase in ammonium transport and signaling by the ammonium permease Mep2 in Candida albicans

    Eukaryot Cell
    10:332-342

    Dunkel N, Morschhäuser J (2011)
    Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4
    D sap5D sap6D mutant
    Eukaryot Cell
    10:54-62

    Heilmann CJ, Schneider S, Barker KS, Rogers PD, Morschhäuser J (2010)
    An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans

    Antimicrob Agents Chemother
    54:353-359

    Dabas N, Schneider S, Morschhäuser J (2009)
    Mutational analysis of the Candida albicans ammonium permease Mep2p reveals residues required for ammonium transport and signaling

    Eukaryot Cell
    8:147-160
     

    Schubert S, Rogers PD, Morschhäuser J (2008)
    Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains

    Antimicrob Agents Chemother
    52:4274-4280


    Dunkel N, Blass J, Rogers PD, Morschhäuser J (2008)

    Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

    Mol Microbiol
    69:827-840

    Dabas N, Morschhäuser J (2008)
    A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans

    Mol Microbiol
    69:586-602
     

    Dunkel N, Liu TT, Barker KS, Homayouni R, Morschhäuser J, Rogers PD (2008)
    A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate

    Eukaryot Cell
    7:1180-1190
     

    Ramírez-Zavala B, Reuß O, Park Y-N, Ohlsen K, Morschhäuser J (2008)
    Environmental induction of white-opaque switching in Candida albicans

    PLoS Pathog
    4:e1000089
     

    Staib P, Lermann U, Blaß-Warmuth J, Degel B, Würzner R, Monod M, Schirmeister T, Morschhäuser J (2008)
    Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening

    Antimicrob Agents Chemother
    52:146-156
     

    Morschhäuser J, Barker KS, Liu TT, Blaß-Warmuth J, Homayouni R, Rogers PD (2007)
    The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

    PLoS Pathog
    3:e164
     

    Dabas N, Morschhauser J (2007)
    Control of ammonium permease expression and filamentous growth by the GATA transcription factors GLN3 and GAT1 in Candida albicans

    Eukaryot Cell
    6:875-888
     

    Hiller D, Stahl S, Morschhäuser J (2006)
    Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate

    Antimicrob Agents Chemother
    50:2300-2308
     

    Bader T, Schröppel K, Bentink S, Agabian N, Köhler G, Morschhäuser J (2006)
    Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain

    Infect Immun
    74:4366-4369
     

    Reuß O, Morschhäuser J (2006)
    A family of oligopeptide transporters is required for growth of Candida albicans on proteins

    Mol Microbiol
    60:795-812
     

    Hiller D, Sanglard D, Morschhäuser J (2006)
    Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans

    Antimicrob Agents Chemother
    50:1365-1371

     

    Park Y‑N, Morschhäuser J (2005)

    Candida albicans MTLa tup1D mutants can reversibly switch to mating-competent, filamentous growth forms

    Mol Microbiol 58:1288-1302
     

    Park Y-N, Morschhäuser J (2005)
    Tetracycline-inducible gene expression and gene deletion in Candida albicans

    Eukaryot Cell
    4:1328-1342
     

    Biswas K, Morschhäuser J (2005)
    The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans

    Mol Microbiol
    56:649-669
     

    Staib P, Morschhäuser J (2005)
    Differential expression of the NRG1 repressor controls species-specific regulation of chlamydospore development in Candida albicans and Candida dubliniensis

    Mol Microbiol
    55:637-652
     

    Reuß O, Vik A, Kolter R, Morschhäuser J (2004)
    The SAT1 flipper, an optimized tool for gene disruption in Candida albicans

    Gene
    341:119-127
     

    Staib P, Binder A, Kretschmar M, Nichterlein T, Schröppel K, Morschhäuser J (2004)
    Tec1p-independent activation of a hypha-associated Candida albicans virulence gene during infection

    Infect Immun
    72:2386-2389
     

    Bader T, Bodendorfer B, Schröppel K, Morschhäuser J (2003)
    Calcineurin is essential for virulence in Candida albicans

    Infect Immun
    71:5344-5354
     

    Michel S, Ushinsky S, Klebl B, Leberer E, Thomas D, Whiteway M, Morschhäuser J (2002)
    Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes

    Mol Microbiol
    46:269-280
     

    Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
    Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene

    Mol Microbiol
    44:1351-1366
     

    Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
    Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection

    Infect Immun
    70:921-927
     

    Wirsching S, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)
    MDR1-mediated drug resistance in Candida dubliniensis

    Antimicrob Agents Chemother
    45:3416-3421

    Strauß A, Michel S, Morschhäuser J (2001)
    Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans

    J Bacteriol
    183:3761-3769

     
    Staib P, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)

    Isogenic strain construction and gene targeting in Candida dubliniensis

    J Bacteriol
    183:2859-2865

    Wirsching S, Michel S, Morschhäuser J (2000)
    Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates

    Mol Microbiol
    36:856-865
     

    Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2000)
    Differential activation of a Candida albicans virulence gene family during infection

    Proc Natl Acad Sci U S A
    97:6102-6107
     

    Wirsching S, Michel S, Köhler G, Morschhäuser J (2000)
    Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor

    J Bacteriol
    182:400-404
     

    Morschhäuser J, Michel S, Staib P (1999)
    Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination

    Mol Microbiol
    32:547-556


    Staib P, Kretschmar M, Nichterlein T, Köhler G, Michel S, Hof H, Hacker J, Morschhäuser J (1999)
    Host-induced, stage-specific virulence gene activation in Candida albicans during infection

    Mol Microbiol
    32:533-546

    Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J (1998)
    Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains

    Antimicrob Agents Chemother
    42:3065-3072 

     

    Review articles

    Morschhäuser J (2016)
    The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen

    J Microbiol
    54:192-201
     

    Morschhäuser J (2010)
    Regulation of white-opaque switching in Candida albicans

    Med Microbiol Immunol
    199:165-172
     

    Morschhäuser J (2010)
    Regulation of multidrug resistance in pathogenic fungi

    Fungal Genet Biol 47:94-106