Selected publications

Original articles

Popp C, Hampe IAI, Hertlein T, Ohlsen K, Rogers PD, Morschhäuser J (2017)
Competitive fitness of fluconazole-resistant clinical Candida albicans strains
Antimicrob Agents Chemother 61:e00584-17

Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J (2017)
The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans
Mol Microbiol 104:989-1007

Ene IV, Lohse MB, Vladu AV, Morschhäuser J, Johnson AD, Bennett RJ (2016)
Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells   
mBio 7:e01269-16

Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD (2016)
Systematic genetic screen for transcriptional regulators of the Candida albicans white-opaque switch
Genetics 203:1679-1692

Tebung WA, Choudhury BI, Tebbji F, Morschhäuser J, Whiteway M (2016)
Rewiring of the Ppr1 zinc cluster transcription factor from purine catabolism to pyrimidine biogenesis in the Saccharomycetaceae
Curr Biol 26:1677-1687

Schneider S, Morschhäuser J (2015)
Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors
Antimicrob Agents Chemother 59:558-569

Ramírez-Zavala B, Mogavero S, Schöller E, Sasse C, Rogers PD, Morschhäuser J (2014)
SAGA/ADA complex subunit Ada2 is required for Cap1-, but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1
Antimicrob Agents Chemother 58:5102-5110

Pannanusorn S, Ramírez-Zavala B, Lünsdorf H, Agerbert B, Morschhäuser J, Römling U (2014)
Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis
Eukaryot Cell 13:438-451

Ramírez-Zavala B, Weyler M, Gildor T, Schmauch C, Kornitzer D, Arkowitz R, Morschhäuser J (2013)
Activation of the Cph1-dependent MAP kinase signaling pathway induces white-opaque switching in Candida albicans
PLoS Pathog 9:e1003696.

Schillig R, Morschhäuser J (2013)
Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activation
Mol Microbiol 89:1003-1017.

Dunkel N, Hertlein T, Franz R, Reuß O, Sasse C, Schäfer T, Ohlsen T, Morschhäuser J (2013)
Role of different peptide transporters in nutrient acquisition in Candida albicans
Eukaryot Cell 12:520-528.

Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J (2013)
White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion
Eukaryot Cell 12:50-58

Sasse C, Dunkel N, Schäfer T, Schneider S, Dierolf F, Ohlsen K, Morschhäuser J (2012)
The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans
Mol Microbiol 86:539-556

Sasse C, Schillig R, Reimund A, Merk J, Morschhäuser J (2012)
Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1
Antimicrob Agents Chemother 56:4490-4494

Schubert S, Popp C, Rogers PD, Morschhäuser J (2011)
Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1
Eukaryot Cell 10:1110-1121

Schubert S, Barker KS, Znaidi S, Schneider S, Dierolf F, Dunkel N, Aid M, Boucher G, Rogers PD, Raymond M, Morschhäuser J (2011)
Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans
Antimicrob Agents Chemother 55:2212-2223

Mogavero S, Tavanti A, Senesi S, Rogers PD, Morschhäuser J (2011)
Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1
Antimicrob Agents Chemother 55:2061-2066

Neuhäuser B, Dunkel N, Satheesh SV, Morschhäuser J (2011)
Role of the Npr1 kinase in ammonium transport and signaling by the ammonium permease Mep2 in Candida albicans
Eukaryot Cell 10(3):332-342

Dunkel N, Morschhäuser J (2011)
Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Delta sap5Delta sap6Delta mutant
Eukaryot Cell 10:54-62

Heilmann CJ, Schneider S, Barker KS, Rogers PD, Morschhäuser J (2010)
An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans
Antimicrob Agents Chemother 54:353-359

Dabas N, Schneider S, Morschhäuser J (2009)
Mutational analysis of the Candida albicans ammonium permease Mep2p reveals residues required for ammonium transport and signaling
Eukaryot Cell 8:147-160

Schubert S, Rogers PD, Morschhäuser J (2008)
Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains
Antimicrob Agents Chemother 52:4274-4280

Dunkel N, Blass J, Rogers PD, Morschhäuser J (2008)
Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
Mol Microbiol 69:827-840

Dabas N, Morschhäuser J (2008)
A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans
Mol Microbiol 69:586-602

Dunkel N, Liu TT, Barker KS, Homayouni R, Morschhäuser J, Rogers PD (2008)
A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate
Eukaryot Cell 7:1180-1190

Ramírez-Zavala B, Reuß O, Park Y-N, Ohlsen K, Morschhäuser J (2008)
Environmental induction of white-opaque switching in Candida albicans
PLoS Pathog 4:e1000089

Staib P, Lermann U, Blaß-Warmuth J, Degel B, Würzner R, Monod M, Schirmeister T, Morschhäuser J (2008)
Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
Antimicrob Agents Chemother 52:146-156

Morschhäuser J, Barker KS, Liu TT, Blaß-Warmuth J, Homayouni R, Rogers PD (2007)
The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
PLoS Pathog 3(:e164

Dabas N, Morschhauser J (2007)
Control of ammonium permease expression and filamentous growth by the GATA transcription factors GLN3 and GAT1 in Candida albicans
Eukaryot Cell 6:875-888

Hiller D, Stahl S, Morschhäuser J (2006)
Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate
Antimicrob Agents Chemother 50:2300-2308

Bader T, Schröppel K, Bentink S, Agabian N, Köhler G, Morschhäuser J (2006)
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
Infect Immun 74:4366-4369

Reuß O, Morschhäuser J (2006)
A family of oligopeptide transporters is required for growth of Candida albicans on proteins
Mol Microbiol 60:795-812

Hiller D, Sanglard D, Morschhäuser J (2006)
Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans
Antimicrob Agents Chemother 50:1365-1371

Park YN, Morschhäuser J (2005)
Candida albicans MTLa tup1D mutants can reversibly switch to mating-competent, filamentous growth forms
Mol Microbiol 58:1288-1302

Park YN, Morschhäuser J (2005)
Tetracycline-inducible gene expression and gene deletion in Candida albicans
Eukaryot Cell 4:1328-1342

Biswas K, Morschhäuser J (2005)
The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans
Mol Microbiol 56:649-669

Staib P, Morschhäuser J (2005)
Differential expression of the NRG1 repressor controls species-specific regulation of chlamydospore development in Candida albicans and Candida dubliniensis
Mol Microbiol 55:637-652

Reuß O, Vik A, Kolter R, Morschhäuser J (2004)
The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
Gene 341:119-127

Staib P, Binder A, Kretschmar M, Nichterlein T, Schröppel K, Morschhäuser J (2004)
Tec1p-independent activation of a hypha-associated Candida albicans virulence gene during infection
Infect Immun 72:2386-2389

Bader T, Bodendorfer B, Schröppel K, Morschhäuser J (2003)
Calcineurin is essential for virulence in Candida albicans
Infect Immun 71:5344-5354

Michel S, Ushinsky S, Klebl B, Leberer E, Thomas D, Whiteway M, Morschhäuser J (2002)
Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes
Mol Microbiol 46:269-280

Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene
Mol Microbiol 44:1351-1366

Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2002)
Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection
Infect Immun 70:921-927

Wirsching S, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)
MDR1-mediated drug resistance in Candida dubliniensis
Antimicrob Agents Chemother 45:3416-3421

Strauß A, Michel S, Morschhäuser J (2001)
Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans
J Bacteriol 183:3761-3769

Staib P, Moran GP, Sullivan DJ, Coleman DC, Morschhäuser J (2001)
Isogenic strain construction and gene targeting in Candida dubliniensis
J Bacteriol 183:2859-2865

Wirsching S, Michel S, Morschhäuser J (2000)
Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
Mol Microbiol 36:856-865

Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J (2000)
Differential activation of a Candida albicans virulence gene family during infection
Proc Natl Acad Sci U S A 97:6102-6107

Wirsching S, Michel S, Köhler G, Morschhäuser J (2000)
Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor
J Bacteriol 182:400-404

Morschhäuser J, Michel S, Staib P (1999)
Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination
Mol Microbiol 32:547-556

Staib P, Kretschmar M, Nichterlein T, Köhler G, Michel S, Hof H, Hacker J, Morschhäuser J (1999)
Host-induced, stage-specific virulence gene activation in Candida albicans during infection
Mol Microbiol 32:533-546

Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J (1998)
Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
Antimicrob Agents Chemother 42:3065-3072

Review articles

Morschhäuser J (2016)
The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen
J Microbiol 54:192-201

Morschhäuser J (2010)
Regulation of white-opaque switching in Candida albicans
Med Microbiol Immunol 199:165-172

Morschhäuser J (2010)
Regulation of multidrug resistance in pathogenic fungi
Fungal Genet Biol 47:94-106