Selected Publications (from a total of 113)
Firdessa R, Good L, Amstalden MC, Chindera K, Kamaruzzaman NF, Schultheis M, Röger B, Hecht N, Oelschlaeger TA, Meinel L, Lühmann T, Moll H (2015)
Pathogen- and host-directed antileishmanial effects mediated by polyhexanide (PHMB)
PLoS Negl Trop Dis 2;9(10):e0004041
Firdessa R, Oelschlaeger TA, Moll H (2014)
Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake: relevance for drug delivery systems
Eur J Cell Biol 93:323-37
Gonzalez-Leal IJ, Roeger B, Schwarz A, Schirmeister T, Reinheckel T, Lutz MB, Moll H (2014)
Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection
PLoS Negl Trop Dis 8: e3194
Glaser J, Schultheis M, Hazra S, Hazra B, Moll H, Schurigt U, Holzgrabe U (2014)
Antileishmanial lead structure from nature: Analysis of structure-activity relationships of a compound library derived from
caffeic acid bornyl ester
Molecules 19: 1394-1410
Bringmann G, Thomale K, Bischof S, Schneider C, Schultheis M, Schwarz T, Moll H, Schurigt U (2013)
A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for the discovery and evaluation of a new class of leishmanicidal quinolinium salts
Antimicrob Agents Chemother 57: 3003-3011
Schwarz T, Remer KA, Nahrendorf W, Masic A, Siewe L, Müller W, Roers A, Moll H (2013)
T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell-based vaccine
PLoS Pathog 9: e1003476
Masic A, Hurdayal R, Nieuwenhuizen N E, Brombacher F, Moll H (2012)
Dendritic cell-mediated vaccination relies on Interleukin-4 Receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice
PLoS Negl Trop Dis 6(7): e1721
Ghosh S, Debnath S, Hazra S, Hartung A, Thomale K, Schultheis M, Kapkova P, Schurigt U, Moll H, Holzgrabe U, Hazra B (2011)
Valeriana wallichii root extracts and fractions with activity against Leishmania spp.
Parasitol Res 108(4):861-871
Bringmann G, Hertlein-Amslinger B, Kajahn I, Dreyer M, Brun R, Moll H, Stich A, Ioset KN, Schmitz W, Ngoc LH (2011)
Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities
Phytochemistry 72(1):89-93
Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H (2010)
Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.
Antimicrob Agents Chemother 54(12):5028-5041
Schnitzer JK, Berzel S, Fajardo-Moser M, Remer KA, Moll H (2010)
Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major
Vaccine 28(36):5785-5793
Remer KA, Roeger B, Hambrecht C, Moll H (2010)
Natural killer cells support the induction of protective immunity during dendritic cell-mediated vaccination against Leishmania major
Immunology 131(4):570-582
Ponte-Sucre A, Gulder T, Gulder TA, Vollmers G, Bringmann G, Moll H (2010)
Alterations to the structure of Leishmania major induced by N-arylisoquinolines correlate with compound accumulation and disposition
J Med Microbiol 59(Pt 1):69-75
Pimentel-Elardo SM, Kozytska S, Bugni TS, Ireland CM, Moll H, Hentschel U (2010)
Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges
Mar Drugs 8(2):373-380
Schurigt U, Moll H (2009)
Drug discovery and development of vaccination strategies for the treatment and prevention of cutaneous leishmaniasis
Pharm Unserer Zeit 38(6):532-537
Remer KA, Bartrow M, Roeger B, Moll H, Sonnenborn U, Oelschlaeger TA (2009)
Split immune response after oral vaccination of mice with recombinant Escherichia coli Nissle 1917 expressing fimbrial adhesin K88
Int J Med Microbiol 299(7):467-478
Ponte-Sucre A, Gulder T, Wegehaupt A, Albert C, Rikanovic C, Schaeflein L, Frank A, Schultheis M, Unger M, Holzgrabe U, Bringmann G, Moll H (2009)
Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts
J Med Chem 52(3):626-636
Fajardo-Moser M, Berzel S, Moll H (2008)
Mechanisms of dendritic cell-based vaccination against infection
Int J Med Microbiol 298(1-2):11-20
Remer KA, Apetrei C, Schwarz T, Linden C, Moll H (2007)
Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice
Eur J Immunol, 37(9):2463-2473
Ponte-Sucre A, Faber JH, Gulder T, Kajahn I, Pedersen SE, Schultheis M, Bringmann G, Moll H (2007)
Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major.
Antimicrob Agents Chemother, 51(1):188-194.
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, P. Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC (2007)
Bis-acridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro
Antimicrob Agents Chemother 51(6):2164-2172
Muth M, Hoerr V, Glaser M, Ponte-Sucre A, Moll H, Stich A, Holzgrabe U (2007)
Antitrypanosomal activity of quaternary naphthalimide derivatives
Bioorg Med Chem Lett 17(6):1590-1593
Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T (2006)
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents
Bioorg Med Chem Lett 16(10):2753-2757
Ponte-Sucre A, Vicik R, Schultheis M, Schirmeister T, Moll H (2006)
Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity
Antimicrob Agents Chemother 50(7):2439-2447
Moll H (2006)
Dendritic cells in leishmaniasis: Regulators of immunity and tool for new immune intervention strategies
In: Handbook of Dendritic Cells – Biology, Diseases and Therapies, (eds. Lutz MB, Steinkasserer A, Romani N), Wiley-VCH, Weinheim, Germany, pp. 669-691
Körner U, Fuss V, Steigerwald J, Moll H (2006)
Biogenesis of Leishmania major-harboring vacuoles in murine dendritic cells
Infect Immun 74(2):1305-1312
Bringmann G, Kajahn I, Reichert M, Pedersen SE, Faber JH, Gulder T, Brun R, Christensen SB, Ponte-Sucre A, Moll H, Heubl G, Mudogo V (2006)
Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese ancistrocladus species
J Org Chem 71(25):9348-9356
Steigerwald M, Moll H (2005)
Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity
Infect Immun 73(4):2564-2567
Ramirez-Pineda JR, Froehlich A, Berberich C, Moll H (2004)
Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC
J Immunol 172:6281-6289
Moll H (2004)
Antigen delivery by dendritic cells
Int J Med Microbiol 294(5):337-344
Moll H (2003)
Dendritic cells as a tool to combat infectious diseases
Immunol Lett 85(2):153-157
Berberich C, Ramirez-Pineda JR, Hambrecht C, Alber G, Skeiky YA, Moll H (2003)
Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens
J Immunol 170(6):3171-3179
Moll H, Scharner A, Kämpgen E (2002)
Increased interleukin 4 (IL-4) receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells infected with Leishmania major
Infect Immun 70(3):1627-1630
Ritter U, Moll H (2000)
Monocyte chemotactic protein-1 stimulates the killing of leishmania major by human monocytes, acts synergistically with IFN-gamma and is antagonized by IL-4
Eur J Immunol 30(11):3111-3120
Flohé SB, Bauer C, Flohé S, Moll H (1998)
Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major
Eur J Immunol 28(11):3800-3811
Erb KJ, Holloway JW, Sobeck A, Moll H, Le Gros G (1998)
Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia
J Exp Med, 187(4):561-569
Flohé S, Lang T, Moll H (1997)
Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major
Infect Immun 65(8):3444-3450
Lanzer M, Gross U, Moll H (1997)
Mechanisms of parasite persistence and immune evasion
Parasitol Today 13:1-3
Ritter U, Moll H, Laskay T, Bröcker E, Velazco O, Becker I, Gillitzer R (1996)
Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis
J Infect Dis 173(3):699-709
Moll H (1996)
Immune responses to parasites: the art of distinguishing the good from the bad
Immunol Today 17(12):551-552
Blank C, Bogdan C, Bauer C, Erb K, Moll H (1996)
Murine epidermal Langerhans cells do not express inducible nitric oxide synthase
Eur J Immunol 26(4):792-796
Moll H, Flohé S, Röllinghoff M (1995)
Dendritic cells in Leishmania major-immune mice harbor persistent parasites and mediate an antigen-specific T cell immune response
Eur J Immunol 25(3):693-699
Moll H, Fuchs H, Blank C, Röllinghoff M (1993)
Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells
Eur J Immunol 23(7):1595-1601
Moll H (1993)
Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis
Immunol Today 14(8):383-387
Moll H (1993)
Development of helper T cell subsets: a central role for interleukin 12
Trends Microbiol 1(6):209-210
Blank C, Fuchs H, Rappersberger K, Röllinghoff M, Moll H (1993)
Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major
J Infect Dis 167(2):418-425
Will A, Blank C, Röllinghoff M, Moll H (1992)
Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis
Eur J Immunol 22(6):1341-1347
Moll H, Müller C, Gillitzer R, Fuchs H, Röllinghoff M, Simon MM, Kramer MD (1991)
Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease
Infect Immun, 59(12):4701-4705
Moll H, Röllinghoff M (1990)
Resistance to murine cutaneous leishmaniasis is mediated by TH1 cells, but disease-promoting CD4+ cells are different from TH2 cells
Eur J Immunol 20(9):2067-2074
Moll H, Scollay R (1989)
L3T4+ T cells promoting susceptibility to murine cutaneous leishmaniasis express the surface marker Ly-24 (Pgp-1)
Eur J Immunol 19(2):307-314
Moll H, Mitchell GF, McConville MJ, Handman E (1989)
Evidence of T-cell recognition in mice of a purified lipophosphoglycan from Leishmania major
Infect Immun 57(11):3349-3356
Moll H, Scollay R, Mitchell GF (1988)
Resistance to cutaneous leishmaniasis in nude mice injected with L3T4+ T cells but not with Ly-2+ T cells
Immunol Cell Biol 66 ( Pt 1):57-63
Kramer MD, Binninger L, Schirrmacher V, Moll H, Prester M, Nerz G, Simon MM (1986)
Characterization and isolation of a trypsin-like serine protease from a long-term culture cytolytic T cell line and its expression by functionally distinct T cells
J Immunol 136(12):4644-4651
Simon MM, Nerz G, Prester M, Moll H (1985)
Immunoregulation by mouse T cell clones. III. Cloned H-Y-specific cytotoxic T cells secrete a soluble mediator(s) that inhibits cytotoxic responses by acting on both Lyt-2- and L3T4- lymphocytes
Eur J Immunol 15(8):773-783
Moll H, Eichmann K, Simon MM (1985)
Immunoregulation by mouse T-cell clones. II. The same H-Y-specific T helper clone can provide help for the generation of cytotoxic lymphocytes and antibody-secreting cells
Immunology 54(2):255-264
Simon MM, Moll H, Prester M, Nerz G, Eichmann K (1984)
Immunoregulation by mouse T-cell clones. I. Suppression and amplification of cytotoxic responses by cloned H-Y-specific cytolytic T lymphocytes
Cell Immunol 86(1):206-221